ﺳﺮواﭘﯿﺪﻣﯿﻮﻟﻮژيSARS-CoV-2 در ﮐﻮدﮐﺎن ﺑﺪون ﻋﻼﻣﺖ ﺷﻬﺮ ﺗﻬﺮان

Seroepidemiology of SARS-CoV-2 Among Asymptomatic Children in Tehran

اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺎ ﻫﺪف ﺑﺮرﺳﯽ ﺳﺮواﭘﯿﺪﻣﯿﻮﻟﻮژﯾﮏ ﺳﺎﺑﻘﻪ اﺑﺘﻼ ﺑﻪ ﻋﻔﻮﻧﺖ وﯾﺮوس ﺳﻨﺪروم ﺗﻨﻔﺴﯽ ﺣﺎد ﺷﺪﯾﺪ )2-SARS-CoV( در ﮐﻮدﮐﺎن ﺑﺪون ﻋﻼﺋﻢ ﺑﺎﻟﯿﻨﯽ ﺷﻬﺮ ﺗﻬﺮان اﻧﺠﺎم ﺷﺪه اﺳﺖ. روش ﮐﺎر: در اﯾﻦ ﺑﺮرﺳﯽ ﻧﻤﻮﻧﻪ ﻫﺎي ﺧﻮن ﮐﻮدﮐﺎن زﯾﺮ14ﺳﺎل ﺷﻬﺮ ﺗﻬﺮان از اﺑﺘﺪاي ﭘﺎﯾﯿﺰ 1399 ﺗﺎ اﺑﺘﺪاي ﺗﺎﺑﺴﺘﺎن 1400 از ﻧﻈﺮ ﺣﻀﻮر آﻧﺘﯽ ﺑﺎدي IgG ﻋﻠﯿﻪ 2-SARS-CoV( وﯾﺮوس ﺳﻨﺪروم ﺗﻨﻔﺴﯽ ﺣﺎد ﺷﺪﯾﺪ، ﺑﺎ اﺳﺘﻔﺎده از ﮐﯿﺖ اﻻﯾﺰاي EUROIMMUN ﺗﺤﺖ ﺑﺮرﺳﯽ ﻗﺮار داده ﺷﺪﻧﺪ. اﻃﻼﻋﺎت دﻣﻮﮔﺮاﻓﯿﮏ و وﺿﻌﯿﺖ اﺑﺘﻼ در ﺷﺮﮐﺖ ﮐﻨﻨﺪﮔﺎن از ﻃﺮﯾﻖ ﺗﮑﻤﯿﻞ ﭘﺮﺳﺶ ﻧﺎﻣﻪﻫﺎ ﮔﺰارش و ارﺗﺒﺎط ﺑﯿﻦ ﻣﺘﻐﯿﺮﻫﺎ ﺗﻮﺳﻂ آزﻣﻮن آﻣﺎري ﺑﺮرﺳﯽ ﮔﺮدﯾﺪ. ﻧﺘﺎﯾﺞ: از ﻣﯿﺎن 1142 ﻧﻤﻮﻧﻪ ﺟﻤﻊآوري ﺷﺪه از ﮐﻮدﮐﺎن ﻓﺎﻗﺪ ﻋﻼﺋﻢ ﺑﺎﻟﯿﻨﯽ ﮐﻮوﯾﺪ-19، ﺳﺎﺑﻘﻪ اﺑﺘﻼ ﺑﻪ 2-SARS-CoV در 33/3% )381/1142( از آﻧﻬﺎ ﺷﻨﺎﺳﺎﯾﯽ ﮔﺮدﯾﺪ. ﺗﻌﺪاد ﻧﻤﻮﻧﻪ ﻫﺎي ﻣﺜﺒﺖ در دﺧﺘﺮان 34/1% و ﭘﺴﺮان 33%/03 ﺑﻪ دﺳﺖ آﻣﺪ. ﻧﺘﺎﯾﺞ ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﻧﺸﺎن داد اﺧﺘﻼف ﻣﻌﻨﺎداري ﺑﯿﻦ ﺳﺎﺑﻘﻪ اﺑﺘﻼ ﺑﺎ ﺳﻦ، ﺗﻌﺪاد اﻋﻀﺎي ﺧﺎﻧﻮاده، ﺑﯿﻤﺎري زﻣﯿﻨﻪ اي، ﺟﻨﺴﯿﺖ و ﺷﻐﻞ ﺧﺎﻧﻮاده وﺟﻮد ﻧﺪارد. ﺑﺮرﺳﯽ ﻧﺘﺎﯾﺞ ﺗﻮزﯾﻊ ﻓﺮاواﻧﯽ ﻓﺼﻠﯽ اﺑﺘﻼ در ﮐﻮدﮐﺎن ﺗﺤﺖ ﺑﺮرﺳﯽ ﻣﻮﯾﺪ ﮐﺎﻫﺶ ﻣﻌﻨﺎدار اﺑﺘﻼ در ﻓﺼﻞ ﭘﺎﯾﯿﺰ ﺳﺎل 1399در ﻣﻘﺎﯾﺴﻪ ﺑﺎ زﻣﺴﺘﺎن 1399 و ﺑﻬﺎر 1400 ﺑﻮد. ﻧﺘﯿﺠﻪ ﮔﯿﺮي: اﺑﺘﻼ ﺑﻪ2 -SARS-CoV در ﮐﻮدﮐﺎن ﻣﯽ ﺗﻮاﻧﺪ ﺑﺪون ﺑﺮوز ﻋﻼﺋﻢ ﺑﺎﻟﯿﻨﯽ ﺑﺎﺷﺪ. ﻫﻤﭽﻨﯿﻦ ﻣﯿﺰان اﯾﻦ اﺑﺘﻼ ﺑﺎ اﻓﺰاﯾﺶ ﺳﻦ ارﺗﺒﺎط ﻣﺴﺘﻘﯿﻢ دارد.

The objective of this study was to determine the seroepidemiological history of SARS-CoV-2 infection among asymptomatic children in Tehran. Materials and Methods: Blood samples of children younger than 14 years old were collected during the period autumn-winter 2020 and spring 2021 and tested for SARS-CoV-2 IgG antibody using the EUROIMMUN ELISA kit. In addition, questionnaires were used to collect demographic and infection status information in the participants. Data were analyzed using the SPSS software. Results: Out of the 1142 children collected from the children with no COVID-19 symptoms, 33.3% (381/1142) were found to have had a history of SARS-CoV-2. The positive samples in girls and boys were 34.1% and 33.03%, respectively. Analysis of the data showed no statistically significant differences between the infection rate on the one hand and age, family size, underlying diseases, gender or occupations of the family members on the other hand. In addition, the infection rate was significantly lower in autumn 2020 than in winter 2020 and spring 2021. Conclusion: SARS-CoV-2 infection can occur in children with no clinical symptoms. In addition, the infection rate is in direct correlation with an increase in age of the children.