The purpose of this study was to determine the relationship between understanding the wisdom of e-learning with content engagement, content understanding and evaluation of course content. The research method was descriptive-correlational. The statistical population included all professors of educational sciences in Markazi and Isfahan provinces (73 people) in the academic year 1399-1400. The census sampling method was used due to the limitation of the statistical population, which finally had 66 respondents. The research tool includes 4 categories of researcher-made questionnaires, which are: 1. Questionnaire for understanding the wisdom of e-learning 2. Questionnaire for engaging the content of the course (Shafipour Motlagh, 2019) 3. Questionnaire for understanding the content of the course and 4. Questionnaire for evaluating the content of the course. The content validity of the questionnaire was provided according to the opinions of experts and the validity coefficient of the questionnaire was obtained using Cronbach's alpha equal to 0.93, 0.95, 0.92 and 0.94, respectively. Descriptive statistics (frequency, percentage) and Inferential statistics (Pearson correlation tests, stepwise multiple regression and structural equation modeling) were used.