poor-Responder در بيماران ART همراه با گنادوتروپين براي تحريك تخمدان در سيكل هاي GnRH-a بررسي نتايج حاصل از تجويز ميكرودوز

EVALUATION OF THE EFFECTS OF ADMINISTRATION OF MICRODOSE GnRH-a COMBINATION WITH GONADOTROPINS ON THE STIMULATION OF OVARIES IN ART CYCLES OF POOR RESPONDER PATIENTS

Introduction: GnRH-a+HMG combination is used for controlled ovarian hyperstimulation in IVF cycles. GnRH-a can be used in 2 ways;!) in follicular phase or 2) in luteal phase . There is discrepancy about its effect when used in the follicular phase. In this study, we determined the effects of microdose GnRH-a in Poor-responder patients. Materials & Methods: 61 poor-responders who were candidates for IVF or microinjection used low dose oral contraceptive pills for 21 days and then Bouserelin 40 µg subcutaneously 2 times /day from 3rd day of cycle and HMG 3Amp/day from 5th day of cycle. Datas were analyzed by SPSS chi -Square and Fisher Exact test. Results: Number of follicles, oocytes, embryo and pregnancy rate were determined, and compared with previous cycles. Difference was significant in all cases. (P < 0.05). Pregnancies occurred in 3 patients (5%). Conclusion: Results of this study showed that use of microdose GnRH-a +HMG for controlled ovarian hyperstimulation in IVF cycles can lead to formation of follicles, oocytes and embryoes in poor responders.