منتظر پيوند كليه C بررسي وضعيت كبدي بيماران تحت همودياليز مزمن و مبتلا به هپاتيت

IVER STATUS IN HEMODIALYSIS PATIENTS WITH HCV INFECTION SEEKING RENAL TRANSPLANTATION

The main routes of HCV transmission are blood transfusion and inoclusion. Although, HCV infection is highly prevalent in candidates for renal transplantation, the clinical value still remains unclear. Recent studies have showen that HCV infection may increase the risk of death among patients on maintenance hemodialysis.This prospective cross-sectional study was performed on 93 HCV positive patients with chronic renal failure referred for renal transplantation. Anti HCV was detected for all patients by Elisa II and then determined by RIBA. The mean age of patients was 39.8±13. There were 52.7% men and 47.3% women. The mean of SGOT & SGPT level were 53.1132% and 77.4141% , respectively; this was 1.5 time more than normal level. 51.4% of specimens with SGOT were less than 40,while 74.2% with SGOT were over 40, and had biopsy score more than 5 (P=0.05). Also 56.7% of patients with SGPT had less than 40 and 65.8% with SGPT more than 40 had biopsy score more than 5, which was insignificant (P=0.30). Liver biopsy was performed in 71 patients (76.3%) 2 patients (2.8%) were normal , 62 (87.3%) had chronic hepatitis and chronic hepatitis with hemosiderosis was reported in 7 patients (9.9%) the knodell score in 37.7% of patients was 4 and less than it and the score of 62.3% was more than 5. Further studies with repeat liver biopsies after kidney transplantation are necessary to observe the evalution of HCV- related liver disease after immunosuppressive therapy.