مقايسه سطح خوني هورمون لپتين در بيماران چاق ديابتي و غير ديابتي

COMPARITIVE STUDY OF SERUM LEPTIN LEVELS IN DIABETIC OBESE PATIENTS AND NON-DIABETIC OBESE INDIVIDUALS

Introduction: Leptin was first discovered from the "Ob Gene" by Friedwan and co-workers in 1994. It is a small peptide with 167 amino acids and molecular weight of 16 Kd . It is secreted by adipose tissues. Leptin has two type of receptors in Hypothalamus and other tissues including muscles, liver and intestines. Leptin inhibits neuropeptide Y resulting in decreased appetite and on the other hand increases the basic metabolic rate of the body resulting in homeostasis of body energy. Insulin via the metabolic pathway plays a central role in regulation of energy in the body. Therefore, correlation between these two hormones in control of body energy is controversial. In this study, correlation of these two hormones in diabetes obese and non- diabetic obese individuals was evaluated. Method: 32 diabetic obese and 32 non- diabetic obese individuals with BMI> 30 kg/ m2 were selected. After fasting, blood levels of leptin, insulin and Hb A1C were measured. Results: The results indicate that blood leptin levels increase in both groups as compared to control group (lean individuals). The results also showed that there was a negative correlation between leptin and insulin in the diabetic obese group while this correlation was positive in the other group. Conclusion: These results indicate that these hormones control homeostasis of energy by different mechanisms.