هيپوكمپ در تشنج هاي ايجاد شده به روش كيندلينگ الكتريكي در قشر پيريفورم موش صحرايي CA1 آدنوزين ناحيه A1 نقش گيرنده هاي

The Effects of Adenosione Aireceptors in CAI Region of Hippocamp on Piriform Kindled Ratsa

Introduction: Epilepsy is neuronal disorder and mechanism of this disorder is not understood. In this study the role of adenosine A, receptors of the CAI region of hippocampus on piriform cortex-kindled seizures was investigated in rats. Material and methods: In full kindled animal by daily electrical stimulation drugs N6-cyclohexyladenosinc (CHA), an adenosine A1 receptor agonist at doses of 0.1, 1, 10 an 100 gm and 1,3 dimethy-8-cyclopenthylxanthin (CPT), and adenosine AI receptors at doses 10 and 20 µm. Bilaterally microinjected to CAI region of hippocampus. 24h before drug injection, microinjected ACSF and data are as a control groups. Results: Obtained results showed that in kindled animals, (CHA), decreased the after discharge duration (ADD), stage 5 seizure duration (S5D) and seizure duration (SD), and increased the latency to stage 4 (S4L) significantly. CHA at the doses of 1 µM decreased only ADD and no changed were observed at the doses of 0.1 µM. Bilateral microinjection of (CPT), increased ADD at the dose of 20 significantly, but had no effect on seizure parameters at the dose of 10 µM. Pretreatment of animals with CPT (10 µM) before CHA (10 and 100 µM), reduced the effect of CHA on seizure parameters significantly. Conclusion: Thus, it may be suggested that the hippocampal CAI region may play an important role in relaying or spreading of seizure spikes elicited from the piriform cortex and activation of adenosine A, receptors of this region can prevent these actions.