بررسي تاثير روش هاي مختلف درماني و جراحي بر ميزان بقاي بيماران مبتلا به سرطان سينه

A Study on Effect of Different Surgery and Treatment Methods on Survival of Patients Suffering from Breast Cancer

Introduction: Breast cancer is one of the most prevalent diseases causing the mortality of middle - aged women in developed and developing countries. According to the latest statistics published by the Iranian center on Diseases control in 1995, after skin cancer, Breast cancer is the most prevalent cancer among women in Iran. The percentages of women affected by skin and breast cancers are 15.68% and 14.7% respectively. However, it is noticeable that malignant tumor is the most important and serious type of breast cancer in Iran. Since most of the sufferings from breast cancer want to have more information about the probable consequences of the disease and the duration of their survival. This study was taken up to find out relevant answers to the mentioned questions. Therefore, it is necessity to determine the factors influencing survival time as well as awareness about the period of survival. Methodology: In present study Kaplan-Meier life tables were prepared based of which survival probability for different months after treatment until 5 years assessed. Meanwhile, homogeneity of survival time distribution in different population under study were examined through Wilcoxon and log-rank test. The results revealed no homogeneity of survival time distribution among patients with respect to the first location of tumor emergence, different treatment methods and age groups. In addition, the most appropriate hazard model was developed by of Weibull regression method. Results: The model showed that the survival time of patients treated through surgery method was 1.29 times more than those treated through radiotherapy method. Over survival time of patients treated through simple mastectomy, modified radical mastectomy and extended radical mastectomy were 1.48, 1.46 and 1.34 times more than that of non-surgery method respectively. The study also showed that with the increase in the age of patients, the survival time after treatment was reduced.