در نوزادان زرد بستري )G6PD( بررسي فراواني كمبود آنزيم گلوكز- 6- فسفات دهيدروژناز

Evaluation of Prevalence of Glucose 6-Phosphate Dehydroganse Deficiency (G6PD) in Admitted Jaundiced Newborns

Introduction: Glucose 6-phostphate Dehydroganse (G6PD) deficiency is one of the most common enzymatic disorders with genetic origin. Jaundice is one of the symptoms of G6PD deficiency. This prospective study was performed to evaluate of prevalence of G6PD deficiency in admitted jaundiced newborns. Methods: This prospective study was perfomed in 573 jaundiced newborns were admitted to one university hospitals from September 2000 to March 2003. In all jaundiced newborns, G6PD activity was measured using spot fluorescent method. Results: 33 neonates (28 males and 5 females) had G6PD deficiency. Incidence of G6PD deficiency in jaundiced newborns was 5.76% (8.02% for male and 2.23% for female). The male : female ratio was 6:1. The mean total serum bilirubin concentration was 20.5 mgldl and mean Hb concentration was 15.1 gldl. All of the patients received phototherapy and exchange transfusion in 30.3% were done for this group. Conclusion: This justifies the recommendation to measure of G6PD activity in all cases of neonatal jaundice and screening of the male neonates for G6PD deficiency through examination of the cord blood at birth is suggested.