تاثير دود سيگار بر بروز سكته قلبي و ارتباط آن با سطح فيبر ينوژن و چربي هاي سرم

The Effect of Passive Smoking on Acute Myocardial Infarction and itʹs Relationship with Fibrinogen and Serum Lipids

Passive smoking increases the risk of coronary artery disease up to 20-70%, so the main purpose of this study was to determine the relationship between passive smoking and acute myocardial infarction (AM) and itʹs main risk factors such as plasma levels of fibrinogen (FG) and lipid profiles disturbances in coronary patients and healthy people. This was a case-control study which carried out in 1994. The case group was composed of 164 patients aged 30-69 who suffered from AM1 and hospitalized in coronary care unit (CCU) of university hospitals in Isfahan. In order to have well matched control group, 200 men and women who were living in the neighborhood of case samples and matched according to age and sex were selected. An interview was done from all samples to obtain data related to their smoking habits. After 14 hours fasting period, total cholesterol (T.Qho), triglyceride (TG), LDL-Cholesterol (LDL-C), HDL-Cholesterol (HDL-C) and fibrinogen (FG) was measured. T.test, chi square and Pearson correlation tests were used to analyze data. FG of passive smokers (PS) was more than nonsmokers (NS) in patients and healthy people (P<0.05). Also the serum lipids level of PS was significantly higher than NS in healthy persons; however in patients only LDL-C of PS was more than NS. There was a relation between serum lipids level and PS in healthy people (P<0.05). As there is a significant relation between FG and serum lipids especially in PS persons and also effect of passive smoking on FG and serum lipids, we conclude that these risk factors have synergism effects and smoking banning in general place is most important.