پديد آورندگان :
Jabir Edan ، B University of Babylon - Collage of Medicine - Department of Physiology , Mahdi Kadhim ، H University of Al-Ameed - College of Medicine - Department of Physiology , Resheed Behayaa ، H University of Babylon - Collage of Medicine - Department of Physiology
كليدواژه :
AMH , Ovarian Response , FSH , Assisted Reproductive Technologies ,
چكيده فارسي :
Background and Objective: Assisted reproductive technologies (ART), including in vitro fertilization (IVF) and embryo transfer, have achieved considerable success, largely due to controlled ovarian hyperstimulation (COH). However, there remains a shortage of studies on the estimation of various ovarian response markers linked to the GnRH agonist-controlled ovarian stimulation (COS) regimen. The objective of the current study is to assess the productiveness of Follicle Stimulating Hormone (FSH) and Anti-Mullerian Hormone (AMH) in determining ovarian responses in infertile patients undergoing controlled ovarian stimulation. Methods: This cohort study involved 90 females, aged 20 to 43 years, with primary and secondary infertility lasting between 3 and 13 years, attending the Al-Najef fertility center for ICSI cycles between June 2020 and January 2021. Patients with a history of ovarian surgery, polycystic ovary syndrome (PCOS), and premature ovarian failure (POF) were excluded. FSH and AMH levels were calculated on second 2 of the menstrual cycle, and the association between these indicators and outcome factors was evaluated. Findings: AMH demonstrated a negative link with age and a positive link with the antral follicle count, total number of follicles after induction, and retrieved oocyte count (p 0.05). FSH exhibited a significant negative link by the total number of follicles after induction (p 0.05). AMH demonstrated the best sensitivity and specificity, positive predictive value (PPV) and negative predictive value (NPV) for predicting ovarian response. Specificity, sensitivity, PPV and NPV for AMH with cut-off values 2 ng/mL test providing 84%, 80%, 86%, 57% in comparison to FSH with cut-off values 4 IU/mL yielded 67%, 68%, 50% and 54%, respectively. Conclusion: In conclusion, our findings suggest that AMH is a superior predictor of ovarian response compared to FSH.
