پديد آورندگان :
Fenjan Hasnawi ، Sadeq University of Basrah - College of Agriculture - Department of Food Science , Jabbar Abd Al-Manhel ، Alaa University of Basrah - College of Agriculture - Department of Food Science , Kadhim AL-Younis ، Zena University of Basrah - College of Agriculture - Department of Food Science , B. Altemimi ، Ammar University of Basrah - College of Agriculture - Department of Food Science , Gamal Abedelmaksoud ، Tarek Cairo University - Faculty of Agriculture - Food Science Department , Hesarinejad ، Mohammad Ali Research Institute of Food Science and Technology (RIFST) - Food Processing Department
كليدواژه :
Aspartic protease , Biosynthesis , Industrial applications , Biotechnology ,
چكيده فارسي :
Aspartic proteases play a vital role in diverse biological processes, with microbial variants garnering considerable attention for their commercial potential across various industries. This comprehensive review delves into the intricate aspects of microbial aspartic proteases, encompassing their biosynthesis, genetic regulation, secretion mechanisms, post-translational modifications, characteristics, and emerging applications. The biosynthesis of these proteases involves the translation of corresponding genes into precursor proteins, which undergo a series of processing steps culminating in the formation of mature enzymes. The efficiency of aspartic protease production and commercialization relies heavily on understanding the mechanisms governing their secretion. Notably, post-translational modifications, such as glycosylation and phosphorylation, play a significant role in influencing the activity and stability of these enzymes. The review further explores the substrate specificity and catalytic properties of microbial aspartic proteases, along with their potential applications in the food industry, pharmaceuticals, and biotechnology sectors. In the food industry, these proteases find utility in enhancing flavor, texture, and nutritional value. In the pharmaceutical realm, they contribute to drug discovery and development. Additionally, in biotechnology, microbial aspartic proteases exhibit versatility in applications such as protein engineering, peptide synthesis, and bioremediation. This comprehensive examination provides valuable insights into the multifaceted nature of these enzymes, shedding light on their biosynthesis, genetic regulation, secretion mechanisms, post-translational modifications, characteristics, and promising commercial applications.
