بررسي همبستگي سندرم متابوليك با عوامل عفوني براساس پروژه قلب سالم خليج فارس

The association of metabolic syndrome and Chtamydia pneumoniae, Helicobacter pylori,cytomegalovirus, and hopes simplex virus type 1; a poputa.tion-based study

Background: The metabolic syndrome together with insulin resistance and their consequences are basic factors in pathogenesis of atherosclerosis. Chronic infection with Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), and herpes simplex virus (HSV) has also been implicated in the pathogenesis of atherosclerosis. The infectious aspects of metabolic syndrome have not been investigated. Methods: In a cross-sectional study, we used National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP)-Ill criteria in 1791 subjects, aged 25 years and over, selected by cluster random sampling in three Iranian ports in the northern Persian Gulf. Serum was analyzed for IgG antibodies to C. pneumoniae, HSV-I, H. pylori and CMV using ELISA. Results: An estimated 54.6% of males and 44.9% of females were identified as fulfilling NCEP-ATP III criteria for diagnosing the metabolic syndrome. In multiple logistic regression analysis, metabolic syndrome was found to have a significant association with HSV-l (OR=2.01; p=0.003), H. pylori (OR=1.47; p=0.004), C. pneumoniae (OR=1.69; p<0.0001) in women and a significant association with CMV (OR=1.99; p=0.007), H. pylori (OR=1.62; p=0.001) and C. pneumoniae (OR=I.77; p=0.001) in men. Conclusion: In conclusion, the metabolic syndrome, which occurs very frequently in the general population, has a significant association with chronic viral and bacterial infectious agents. Hypothesis about participation of infection in pathogenesis of metabolic syndrome should be investigated.