مرکز منطقه ای اطلاع رساني علوم و فناوري - بررسي اثر پودر سير روي فشار خون ، ليپيد و ليپوپروتيين هاي سرم خون

چكيده لاتين :

Recently it has been repcrted that garlic extract inhibits LDL Oxidation and minimize oxidized LDL-induced cell injury, in this study, the antioxidant effects of garlic were further examined by determining changes in serum levels of lipids and lipoproteins and also blood pressure in normal individuals following receiving garlc powder. Serum levels of lipids and lipoproteins (cholesterol, Triglyceride, LDL-c and HDL-c) and blood pressure were measured in thirty one apparently healthy male students between 21-25 years old. AH the students were nonsmoker living ii university residency with similar nutritional status, the students received garlic powder (3/400 mg/c) (each Dose equivalent to 1000 microgram Allicin) for four weaks. Then measurement of the parameters were repeated and the results were compared with those of obtained at the begning. Cholesterol, Triglyceride and HDL-c were measured by standard enzgmatic methods. Total lipids was determined colorimetrically usirg phosphoric Acid-Vanllin Reaction and LDL-c Calculated by Friedewald formula and blood pressur was measured with standard method. Using t.test the results obtained before and after taking gar ic powder were compared with each others. Reduction in the serum levels of tctal cholesterol triglyceride, LDL-c, tolal lipids and elevation in the levels of HDL-c and in the HDL-cLDL-c ratio were observed but only in the cases of total lipids and HDL-c/LDL-c ratio the changes vere significant (P<0.05 in both cases). Comparing the results of blood pressures although reduction in systolic and diastolic pressures was noticed but it was not significant (P>0.05). Since elevation in the Levels of tctal Lipids and ratio of HDL-c/LDL-c may promote atherosclerosis garlic may thus be useful for the prevention of atherosclerosis and cardiovascular diseases by reducing formation of oxidized lipids and altering their metabolism