بررسي آنژيوژتر در نيوپلاسم هاي بدخيم تيروييد با استفاده از روش ايمونوهيستوشيمي

The study of Angiogenesis in Malignant Thyroid neoplasms with immunohistochemistry method

Introduction: Thyroid gland cancers are among the common cancers of endocrine glands in which the role of angiogenesis has not been clearly identified and more research seems necessary. Angiogenesis is an essential factor for growth, viabitily and extension of numerous cancers. The major goal of this research is to investigate the role of angiogenesis in malignant thyroid tumors and its relation with clinical and microscopic findings. Materials and methods: ln a descriptive study, 205 paraffin blocks of malignant thyroid lesions were stained with factor 8 by the immunohistochemistry method (avidin-biotin peroxidase). Microvessels in 3 locations having more small vessels were counted, and the mean of microvessels for each case was calculated. Results: Mean vascular counts were 30.9 in papillary carcinoma (Standard Deviation=11.6) (avidin-bioten peroxidase); 35.7 in medullary carcinoma (Standard Deviation=20.4); 29.5 in follicular carcinoma (Standard Deviation=16.0) and 34.0 in anaplastic carcinoma (Standard Deviation=8.9); these results demonstrate that there is no statistical relationship with regard to microvessel count between the aforementioned groups (p value = 0.263). Conclusion: There is no significant difference in regard to angiogenesis between the malignant thyroid tumors studied and there is no statistically significant relationship between angiogenesis and microscopic findings (capsular invasion, vascular invasion and lymph node involvement) as well. This study reveals that in sharp contrast to many other common cancers, the role of angiogenesis in thyroid cancers is not so important and further studies for confirmation of this result are necessary.