در موش هاي صحرايي نربالغ سالم و ديابتي شده توسط استروپتوزوتوسين )OLEAEUROPAEAL.( برري اثر هيپوگليسمي عصاره الكلي برگ زيتون

Hypoglycaemic effect of alcoholic extract of olive (Olea europaea L.) leaf in healthy and diabetic rats

In traditional medicine leaves of olive (Olea europaea L.) are used as a diuretic, hypotensive, antibacterial and antiatherosclerotic. In the present study, oral administration of 0.1, 0.25 and 0.5g/kg body wt. of the alcoholic extract of leaves of olive for 14 days on the level of glucose and insulin in healthy and streptozotocin-induced diabetic rats were evaluated. The results showed that oral administration of the alcoholic extract of olive exhibited a significant reduction in blood glucose and increased plasma insulin in diabetic rats. The extract didnot change the level of blood glucose and plasma insulin in healthy rats significantly. A comparison was made between the action of the alcoholic extract and a known antidiabetic drug, glibenclamide (600 µg/kg body wt.). The hypoglycaemic effect of the extract was greater than that observed with glibenclamide.