بررسي اثرات ترنجبين بر بيلي رو بين خون در موش هاي مبتلا به هيپربيلي روبينمي تجربي

Effects of Taranjebin on serum bilirubin in hyperbilirubinemic suckling rats

Introduction: In the past, medicinal herbs had enormous application in traditional medicine in Iran. At present, Taranjebin a gum of Alhagi herb (Alhagi Mannifera) is used as a medical herb for treatment of jaundice in infants. Thus, the purpose of present study was to investigate the possible therapeutic effects of Taranjebin on a scientific basis. Materials and Methods: Taranjebin solution was made by dissolving Taranjebin in distilled water and then filtered. Wistars offspring rats (body weight: 19-21 gr) were used. Animals were divided into four groups: group one as a negative control, other three groups were injected inetraperitoneal (ip) aminolevulinic acid (ALA) at a specific time after birth, which causes hyperbilirubinemia. Of these three groups, one group was used as a positive control, and the other two as experimental group received Taranjebin and distilled water by gavage, respectively. At different interval times blood samples were drawn and total bilirubin was measured. Results: Results showed that after injection of ALA, plasma bilirubin concentration increased significantly (P<0.05). Oral administration of Taranjebin led to a significant decrease in the level of bilirubin in rats with jaundice as compared with control groups (P<0.05). Conclusion: Thus, a decrease in plasma bilirubin concentration could be due to the degradation or increased bilirubin excretion by this plant resin (Taranjebin).