اسيدهاي چرب امگا - 3 و بهبودي زخم در ديابت

Omega-3 fatty acids and wound healing in diabetes

Introduction: Omega-3 (w-3) fatty acids are proper fat to human. These fats are present mainly in fish or fish oil. The w-3 fatty acids have the potential role in prevention of different diseases,such as diabetes mellitus. Impaired wound healing is well-documented complication in chronic diabetes mellitus. With considering to the mechanism involved in impairment of wound healing in diabetic subject and also the anti-inflammatory effect and/or protective effect against cardiovascular diseases, of fish oil, this oil may have beneficial effects on wound healing, and acceleration of healing. This reviewed investigates the effects of dietary or non-dietary (topically application) intake of w-3 polyunsaturated fatty acids in wound healing, especially diabetic wound.Materials and Methods: Literature review to cause on articles in which effects of w-3 fatty acids and w-6 fatty acids were investigated in wound healing. Results: This review reports evidences on: (1) positive effect of w-3 fatty acids (fish oil) on diabetic wound healing was more than w-6 fatty acids; (2) the effects of fish oil on wound healing in chronic diabetes is less than acute diabetes; (3) in chronic period, the topical application of oil more effective than systemic administration; (4) w-3 fatty acids caused acceleration of wound in diabetes, and other kinds of wound including gastric ulcer, intestinal,colon ulcer, and Burn. (5); more recent research has established on animal wound models (not patients). Conclusion: The data reported in this review may suggest that, fish oil may represent a new class of drugs (agents) that has the beneficial effect on wound healing, for example in diabetic wound.