تعديل حافظه فضايي توسط گيرنده هاي گلوكوكورتيكوييد

Modulation of spatial memory by amygdalaʹs glucocorticoid receptors

Introduction: Previous study indicated that adrenocortical glucocrticoids are effectivness on memory storage in emotional state. There are moderate density of glucocorticoid receptors in basolateral amygdala (BLA) that may be involved in learning and memory. The present experiment examined the role of glucocorticoid antagonist receptor into the basolateral amygdala (BLA) on spatial memory in Morris water Maze task. Materials and Methods: Male Long-Evans strain rats were surgically implanted bilaterally with cannulae aimed at the BLA in the brain and were trained to Morris water Maze task. RU-38486 (3 ng/0.6 ml per side) as a glucocorticoid antagonist were injected bilaterally into BLA pre-training and immediately, 60 and 120 min after training and pri retreival test. The latency time to the fine plexy glass platform and the length of swimming were used to measure the spatial memory. Results: Results indicated that infusion of glucocorticoid antagonist pretraining and immediately and 60 min, but not 120 min after training into BLA significantly impaired retention performance. Injection of the drug before retreival test did not any significant effect on animal performance. Conclusion: The above results show that glucocorticoid receptors plays an important role in acquisition and consolidation of spatial memory in Morris water Maze task at least 60 min after training.