نقش ان - استيلاسيون گالاكتوز و گلوكز در تكامل فوليكول

Evaluation of lectin-binding sites in zona pellucida during ovarian cycle

Introduction: Glycoconjugates, particulary their sugar side chains, play importante roles in development. This investigation was undertaken to examine the chemical nature of components in the zona pellucida possibly related to follicular developmebt. Materials and Methods: To this end, lectins conjugated to horseradish peroxidase were used as specific histochemical probes to characterize the structure of zona pellucida glycoconjugates and changes in their composition during ovarian cycle. Results: Three lectins for N-acetylation of galactose and glucose intensely stained the zona pellucida. Conclusion: These observations suggest that the N-acetylgalactosamine(GalNAc) and N-Acetylglucosamine(GlcNAc)-containing glycoconjugates in zona pellucida may be of functional important in follicular development. We can use this data for causing female infertility and to make special cotraceptive.