بر غده پستاني در موش رت A تاثير سيكلوسپورين

THE EFFECT OF CYCLOSPORIN A ON MAMMARY GLANDS OF RATS

Introduction : Cyclosporin A is one of the immunosuppresive drugs which is applied to decrease the rejection rate of graft after surgical operations, and has numerous side effects. Materials & Methosd : In this studye, the effect of cyclosporin. A on mammary glands of rats was studied. Cyclosporin A was added daily on 12.5g of their feed at dose rate of 20mg/kg body weight for a period of 45 days for 12 experimental rats. twelve control arts were given only the commercial feed. At end of the experiment, the animals were eutthanised and autopsy was performed. Results : No gross or microscopic changes seen in the mammary tissues of control rats. In the experimental animals 3 cases showed gross masses in the mammary glands which histologically studied. There was hyperplasia of the epithelium in mammary ductes with increase , fibros tissue around them. Discussion: This study may bring to light the hyperplastic effect of cyclosporin A on mammary gland of rats.