پلاسمايي A ارتباط بين كاتاراكت پيري و ويتامين

COMPARISION OF PLASMA VITAMIN A LEVEL IN POPULATION WITH AND WITHOUT SENILE CATARACT

Introduction: senile cataract is one of the public health problem at world and it is the most important cause of blindness in old population. Oxidative damage has been considered as a major factor involved in senile cataract. Although the Nutrilional factors including vitamin A with antioxidant property can be implicated as a protective agent. there is a little information about these vitamins status in Iranian population particularly with respect to the cataract. Materials: A population based case-control study was conducted on 102 patients with cataract and 102 healthy volunteers attending the Alavi and Nicokary Ophthalmology Clinics of Tabriz University of Medical Sciences The age were over 45 years old in both groups. The anthropometric measurements were carried out and cappillary blood was drawn to determine plasma vitamin A with HPLC method. A food frequency questionnaire was used to collect information on the consumption of a wide variety of food item. Personal information also collected and blood systolic and diastolic pressure were determined. Differences were considered significant at p< 0.05. Results: Plasma vitamin A level in the patients was found to be significantly lower than the control (0.,150±0.018 ymolil vs 0.61110.022 pmol/l respectively). The nutritional assesment showed that patients with cataract have consumed significantly less food groups including milk, meats, fruits, vegetables and grains. Conclusion:According to this study, patients with cataract has a low plasma vitamin A level compared with normal subjects. The lack of enough information about nutritional intake may play an important role in this matter. Risk factors such as high blood pressure, low literacy, smoking may be effective in cataract formation.