مثبت در تبريز HBSAG مطالعه سرواپيدميولوژيك ويروس هپاتيت دلتا در افراد

SEROEPIDEMIOLOGICAL STUDIES OF HEPATITIS DELTA (HDV) IN HbsAg POSITIVE INDIVIDUALS IN TABRIZ

Introduction : HDV, a defective viroid, is related to hepatitis B virus (HBV). Its epidemicological properties are similar to HBV, and this virus has crucial roles in induction of chronic and fulminant hepatitis. Prevalence of this virus is very variable and HBV control is very useful in HDV control, regarding to this endemic region. Methods & Materials : 130 patients and donors randomly selected and their were studied for anti-HDV (IgM) by using ELISA method. Serum ALT was examined by a routine biochemistry method. All anti-HDV positive serums were also studied for anti-HBc. Results : Eight cases (6.15%) were positive for anti-HDV which 5 cases (7.6%) belonged to HBV+HDV positive patients and remainder (4.6%) belonged to blood donors. In 60% of HBV + HDV positive patients, IgM-HBc was positive. ALT level were abnormal in all HBV+HDV positive sera. Discussion: Since the epidemiological properties of HDV is similar to HBV and the prevalence of HDV in our region (Azarbaijan) is low, this range may be related to controlling of HBV. Like the other findings, the prevalance of HDV in patients with liver diseases is higher than normal donors, so it needs more samples to study. - Although there is no vaccine for HDV, control and management of HBV would be helpful in HDV control.