كليدواژه :
Coronary Artery Disease , E ويتامين , ليپوپروتيين هاي سرم , serum lipioproteins , بيماري عروق كرونر , vitamin , پزشكي
چكيده لاتين :
Background & Aim: Vitamin E has an antioxidant effect and recommended for patients with coronary artery disease (CAD), with dosage of 100mg/day. The antilipidemic effect of vitamin E is contraversial. This study planned for evaluation of antilipidemic effect of vitamin E on serum lipoproteins.
Material & Methods: In this double blind, Placebo controlled clinical trial, we selected 108 consecuative patients (mean age 57±7.2) with CAD and basal low density lipoprotein cholestol (LDL-c) level of 100-130mg/dl, and randomised in two groups, 58 patients in case group and 50 in control group. Case group received protocol of non pharmacological treatment plus 1 tablet of 100mg vitamin E per day, and control group received protocol of nonpharmacological treatment plus 1 tablet of placebo. After I month period lipid profile was measured two time for 1 week apart after 10 hours fasting periods, and mean level was detected. Data analysed statistically and P<0.05 considered significant.
Results: No significant reducation were observed between mean of changes in total cholestrol, HDL-C, triglycerid and LDL-C in female group (p<0.05). In this period after adjusting for non pharmacological treatment, only in male group (46 case) with CAD decrease in LDL-C was observed (11.2% vs 2.8%), but in female group, it was 4.8% in vitamin E group vs 2.4% in controls. Discussion: It can be concluded that 100mg vitamin E per day has no beneficil effect on plasma lipid levels. Decrease in LDL-C level of male group can be due to male hormonel effect of vitamin E that needs further investigation.
