ارتباط ميكروآلبومينوري با وسعت ضايعات آترواسكلروز كرونري

RELATIONSHIP BETWEEN MICROALBUMINURIA AND EXTENSION OF CORONARY ATHEROSCLEROTIC LESIONS

Background & Aim: Microalbuminuria is a diagnostic tool for screening patients at risk of developing nephropathy. It is also known that patients with microalbuminuria have a greater incidence of cardiovascular events and early mortality. In this study reliability of the microalbuminuria as an indicator of a risk of progressive cardiovascular disorders was tested by detecting of the relationship between microalbuminuria and extension of atherosclerotic coronary lesions. Materials and Methods: The subjects for this study were 228 patients with angiographically confirmed coronary atherosclerotic lesions, mean of age 60 referred to Madani Hospital, Tabriz, Iran. Age and sex matched apparently healthy individual (n =114) were used as the control group for comparative study. The levels of glucose and creatinine and that of post parandial glucose were determined in venous blood samples by standard methods. In random sample of urine creatinine with Jaffe method and microalbuminuria with immunoturpidimetric method in auto-analyzer was measured. The results were calculated by using statistical analysis. Results: The results shown that urine albu min ratio was higher than control group (CI=95% p> 0.05). creatinine A direct relationship between microalbuminuria and extension of atherosclerotic coronary lesions was noticed (CI=95% p=0.009). The increased albu min ratio was markedly correlated with diabetes (p=0) creatinine but there was no relation between albu min and other factors significantly (p>0.05). creatinine Discussion: The presented results indicate the existence of significant correlation between extension of atherosclerotic lesions and microalbuminuria. The relationship between diabetes and microalbuminuria was meaningful. These facts may contribute to the higher cardiovascular risk in diabetic patients. An association between hypertension and microalbuminuria was noticed. The results suggest that although risk factors such as hypertension and diabetes are known to cause cardiovascular disease, microalbuminuria may be a contributor indicator of cardiovascular events.