مقايسه كارايي فليوگزتين و كلوميپرامين در درمان اختلال وسواسي - جبري

A COMPARATIVE STUDY OF THERAPEUTIC EFFICACY OF FLUOXETINE AND CLONIIPRAMINE IN OBSESSIVE-COMPULSIVE DISORDER

Background & Aim : Clomipramine, a tricyclic antidepressant agent, and fluoxetin, a selective serotonin reuptake inhibitor , have been shown to be effective in treatment of obsessive - compulsive disorders. This study was carried out to compare the efficacy of fluoxetine and clomipramine in treatment of 110 obsessive - compulsive outpatients. Materials and Methods : 110 obsessive-compulsive outpatients were selected randomly from two psychiatric clinics in Tabriz. At the beginning, patients were devided in to two groups randomly, and in the second phase of the study, they were assigned to three groups, by a sequential sampling. The efficacy of fluoxetine and clomipramine was compared in first and second groups. In the third and fourth groups the patients resistant to each drug were treated with the other drug. In the last phase patient to both drugs were treated by combination of two agents (5 th group). Results : The results showed relative superiority of fluoxetine to clomipramin in some patients with obsessire-compulsive disorder (p <0.01 and p <0.05), but in some cases the difference was not significant. Discussion: Considering the results of the study, fluoxetine is a firstline probably therapeutic agent for obsessive-compulsive disorder and probalily an appropriate pharmacological approach in treating obsessive-compulsive patients in our country.