بررسي رابطه بين سطح آندروژن ها و پروژسترون سرم با پره اكلامپسي در سه ماهه سوم بارداري در زنان نولي پار

EVALUATION OF RELATION OF SERUM ANDROGENS AND PROGESTERONE WITH PREECLAMPSIA IN THE THIRD TRIMESTER OF PREGNANCY

Background & Aim: Hypertensive disorders are one of the most common causes of pregnancy complications. As the pathogenesis of this disease is not clear and as there are so many reasons to prove the role of sex hormones in this disease, so this study tries to investigate the changes of serum progesterone, total testosterone, free testosterone and dehydroepiandrosterone sulfate (DHEAS) levels in the patient with preeclampsia . Materials & Methods: Four above mentioned hormones were compared between nineteen patients with preeclampsia who were referred to Kosar Hospital of Urmia and seventeen normal pregnant selected cases. All subjects in two groups were primigravid women with same gestational age and body mass index. T test was used as a statistical way of analysis. p<0.05 was considered as significant. Results: There were no significant differences in maternal age, gestational age and body mass index. Progesterone and free testosterone levels were significantly lower in patients with preeclampsia than in the control group (p<0.05). There were no significant differences in total testosterone and DHEAS. Discussion: Sex hormone binding globulin increases in preeclampsia, so that it can decrease the amount of free testosterone in serum. On the other hand, progesterone can relax smooth muscle of vessels result in decreasing of blood pressure. It can be concluded that decreasing of progesterone in preeclampsia may play a role it in the pathogenesis of preeclampsia. Of course to sum up everything, so many complementary studies are needed.