عنوان مقاله :
PET به منظور تصويربرداري از گردش خون موضعي به روش [Bn]NH3 توليد آزمايشي ، فرمول بندي و كنترل كيفي راديو داروي
عنوان به زبان ديگر :
Production, formulation and quality control of [13N]NH3 compound for PET imaging of regional blood flow
پديد آورندگان :
اميررضا جليليان ، مترجم ,
كليدواژه :
واكنش هاي هسته اي , كنترل كيفي , نيتروژن -13 , DE VARDA كاتاليزور , پزشكي هسته اي , ) LAL( تست پيروژن , گردش خون موضعي , Regional blood flow , De Vardaʹs catalyst , راديو دارو , 13N , quality control
چكيده لاتين :
In this study, 16O(p,a)13N nuclear reaction was chosen as the best method of N-13 production. High purity natural water targets were bombarded by 18 MeV protons with an intensity of 8/.IA. A production yield of 13.5 mCi/pAh was obtained. Chemical modification of 13N-nitrogen oxides into [13N]NH3 was accomplished using De Vardar catalyst. Chemical, radiochemical and radionuclide purity controls performed on the final product showed high radiopharmaceutical purity (>98%) in the form of [13N]NH3.
[13N]NH3 was formulated in normal saline media at appropriate pH and sterile conditions. Microbial and LAL tests were performed on the final product in order to assure its safety for administration to experimental subjects.
كلمات كليدي :
#تست#آزمون###امتحان
