اثرسم بوتوليسم بر سفتي عضلاني كودكان با فلج مغزي اسپاستيك

The effect of Botulinum Taxin on Spasticity in Children with Cerebral Palsy

The use of botulinum toxin type A (BTA) was studied in 15 children with spastic diplegia to determine its efficacy and tolerability. Nine non-ambulatory and six nonfunctional ambulatory were included. All children received occupational therapy for 6 months. They didnot show any clinical improvement, then BTA were injected. The effect was evident within one week. The peak effect was noticed by one month in the majority. The effect lasted for 3-6 months. All children experienced decreased spasticitiy scores. The peak improvement in active dorsiflexion was noticed in the third month. Their functional status improved, six nonambulatory children becoming more independently ambulatory. Measurement of joint showed improvement in the range of motion as compared with the baseline. Side effects consist of pain at the site of injection and temporary weakness in the four children. This study demonstrated that botulinum toxin type A (BTA) is useful in reducing the spasticity in cerebral palsy.