اثر فنوباربيتال در پيشگيري از بروز خونريزي داخل بطني در نوزادان نارس

Effect of Prophylactic Phenobarbital Intraventricular Hemorrhabe

There are several reports about the effects of postnatal Phenobarbital on intraventricular hemorrhage. This study is carried out to determine the effect of Phenobarbital on prevention Of IVHin preterm infants. In NICU Ghaern Hospital all infants with a birth weight< 1500 grams, gestational age< 34 weeks and with apostnatal age less than 12hs who did not required mechanical ventilation enrolled and randomly assigned to Phenobarbital and control group. Infants in treated group received two loading dose of l0mg/kg/dose of Phenobarbital 12 hours appears, followed by a maintenance dose of 2.5mg/kg every 12 hours for 6 days. Serial brain sonographies were obtained on day 1-3, repeated between day 4-7, and between day 8 until discharge on all of infants. 58 infants < 1500 grams and gestational age< 34 weeks randomly were divided Phenobarbital group (n=26) and control group (N=32). Ten infants (17.2%) developed IVH, which three (11.5%) patients were in Phenobarbital group and seven (21.9%) were in control group, this difference is not significant (p=0.248). There is also no difference in severity of IVH between two groups (p=0.476). This study showed no significant effect of Phenobarbital on prevention or severity of IVH and further studies are needed to recommend Phenobarbital for routine use.