در بيمارستان امام رضا(ع ) مشهد سال 3831 E-TEST بررسي مقاومت سويه هاي استافيلوكوك طلايي در نمونه هاي داخل و خارج بيمارستاني به روش

Evaluation of Antimicrobial Resistance in Community and Nosocomial St. Aureus

Introduction: Staphylococcus aureus is a common pathogen in community-acquired and nosocomial infections , and inappropriate use of antibiotics during recent decades resulted in spreading MRSA isolates. According to some studies 60% of its hospital acquired staphylococcal infections were reported to be resistant to meticillin. The aim of present study was to determine the prevalence of MRSA among clinical isolates in Imarn Reza General Hospital of Mashhad. Material and Methods: In present article we performed E-test and disk diffusion methods to determine the prevalence of MRSA among 115 isolates obtained from different units in Imam Reza general hospital of Mashad. Results: The results show that 69 isolates (60%) were nosocomial and 46 (40%) was community acquired. MRSA was the ethiologic agents in 75.4% of nosocomial infections, while most of community acquired infections (93.3%) were sensitive to metilicillin . Almost all of the isolates obtained from burn unit (30 isolates) were MRSA. All of the isolates were vancomycin sensitive but penicillin resistant by disk diffusion method. From 33 isolates wllich were resistant to metilicillin by E-test, 9 (27.3%) reported sensitive by oxacillin disk; hence its usefulness for practical means remains doubtful. Conclusion: If our results would be confirmed by future studies, it seems that MRSA has a very lligh prevalence in Iran, whose control and eradication demands a very solid and subtle program.