ازدياد حساسيت تاخيري در آدنيت ناشي از واكسن سل در كودكان مراجعه كننده به درمانگاههاي اطفال شيراز در سال 1376

Delayed Hypersensitivity in B.C.G. Adenitis

Complications of B.C.G. immunization are mostly benign. The most common one is adenitis (0.5-5%) especially in axillary area (1,2). The cause of B.C.G. adenitis is unknown. Probably delayed hypersensitivity reaction playing the major role. This study was in two groups of infants with and without adenitis in post immunization period. This study was designed in order to determine the lymphocyte proliferating activity in two patient groups (with and without adenitis). Using both B .C.G. and some other mitogens including PHA and Con A (phytohemagglutinin and Concanavalin A). High lymphocyte proliferation was noticed in-groups who were tested with B.C.G. +Con A or Con A alone (10). Results shown that lymphocyte in patient group (Adenitis group) highly stimulated with Con A, therefore C.M.I, (cell mediated immunity) activity most probably is the cause of BCG adenitis (8,19).