تعيين ميزان حساسيت به پني سيلين در پنوموكوك هاي جدا شده از نمونه هاي باليني بيماران بستري در بيمارستانهاي امام رضا(ع ) وقايم (عج ) مشهد

Evaluation of Sensitivity to Peniciline in Strains of Streptococcus Pneumonia from Inpatients of Imam Reza nd Ghaem Hospital

Introduction:Penicillin has been the choice for treatment of Streptococcus pneumonia infections for a long time , but there are many studies that suggest resistance to penicillin . Penicillin resistance pattern varies in different populations and determination of this pattern is necessary for choosing appropriate antibiotic. MIC determination is the best method for evaluation of antibiotics resistance. Material and Methods: Total 54 strains of Streptococcus pneumonia isolated from inpatients of Imam Reza and Ghaern hospital during one year (2003 - 2004) were included in this surveillance. This research is a descriptive study to evaluate the Penicillin MIC in Streptococcus pneumonia, using E.test ( Episilometery Test ) . Results: Using E.test, 4 patients (7.4%) had Penicillin resistant pneumococci, 34 patients (62.9%) had intermediately resistant pneumococci and 16 patients (29.6 %) had Penicillin sensitive pneumococci. Conclusion: It seems that the most important etiology of Penicillin resistance is incorrect antibiotic prescription and usage. According to this study penicillin should not be used for teratment of some high-risk Pneumococcal infections, such as meningitis.