بررسي تاثير كلريدكادميوم روي گلومرول هاي كليوي جنين و نوزاد موش صحرايي

The Effect of Cadmium Chloride on Kidney glomeruli of Rat Embryo and Neonate

Cadmium(Cd) is an environmental contaminant and an important toxic chemical with teratogenic and embryotoxic effect. Chronic human exposure to Cd will result in kidney injury. The present investigation was conducted to study the effects of cadmium chloride(CdCI2) on structural changes in rat embryo and neonate glomeruli. Thirty female Sprauge-dawley rats with mean weight of 180-240 gr were used in this study. They were classified into 6 quintet groups. On the 9th day of pregnancy, 2mg/kg Cadmium Chloride was injected intraperitoneally in right lower quadrant of abdomen in groups I & III, 4mg/kg in groups II & IV and only 1ml/kg Normal Saline in groups V & VI. Left kidneys were removed in groups I, II & V on the 21st day of pregnancy and in groups III, IV and VI 3 days after the birth. Specimens were fixed with bouinʹs solution and stained with H&E for microscopic changes examination including: glomeruli number, diameter and morphology. The results showed that prenatal exposure to CdC12 can induce significant changes in the histometry and differentiation of glomeruli. Such changes appear to be restricted to the late prenatal and early post-natal period and to occur in the absence of other overt signs of toxicity.