مقايسه اثرات تزريق داخل صفاتي بتامتازون طويل الاثر دگزامتازون و بتامتازون فسفات در جلوگيري از چسبندگي داخل شكمي پس از اعمال جراحي شكم و لگن

COMPARISON OF INTRAPERITONEAL INJECTION AMONG BETAMETHAZONE-LA, DEXAMETHAZONE AND BETHAMETHAZONE PHOSPHATE FOR PREVENTION OF INTRAABDOMINAL ADHESION FORMATION AFTER PELVIC AND ABDOMINAL OPERATION IN RAT

Adhesion bands and adhesion formation is one of the most importants post surgical complication in pelvic and abdominal operations. Post operation adhesions are the most common cause of intestinal obstruction in the western world. Approximatly one-third of all intestinal obstruction are likely to be due to adhesions. In over 10% of infertile women, adhesion formation is the main cause of infertility. Major studies in prevention of adhesion formation have based on anti-inflamatory agent. In this study we decided to compare corticostroid agents in intraperitoneal injection for reduction of postsurgical intraperitoneal adhesions. Forty rats devided to 4 groups (N- 10) and after anesthesia with 5Omg ketaniine intraperitoneally and laparatomy, an abrasion between uterine horns was created and then, 10mg talc powdered in each rat. Also in the group A l Oml normal saline, group B 1 mg/kg betamethazone phosphate, group C l mg/kg dexamethazone and group D lmglkg betamethazone-LA added into peritoneum. Then abdominal wall was repaired. After 4 weeks relaparatomy was done and adhesions with modified Swolin method was registered. In comparison among groups there were statistically significant difference in the rate of adhesions (P=0.04). It showed betamethazone-LA decreases grade of adhesion (P=-0.07). Difference between betamethazone-LA and control group in amount and thickness and strength of adhesion vas statistically significant. In the previous studies multiple intramuscular injection of hetamethaz.one phosphate decreased fibrin formation in rats and multiple dose of dexamethazone intraperitoneally and orally were effective in reducing of adhesions. But at the present study single dose of hetamethazone-LA intraperitoneally reduced rate of adhesion and betamethazone phosphate and dexametazone were ineffective.