مقايسه اثرات درماني ليتيم و پيريدوكسين در اختلال ملال پيش از قاعدگي

Comparison of lithium carbonate and pyridoxine in the treatment of late luteal phase dysphoric disorder (LLPDD)

Background: Late luteal phase dysphoric disorder (LLPDD) is among the most common psychiatric problems within female population. There have been several different suggestions for its treatment with nebulous results. Present study, which was conducted in Imam Hossein hospital compares the efficacy of lithium carbonate and pyridoxine on LLPDD aiming at treating premenstrual syndrome. Methods: Regarding DSM IV Criteria, fifty patients were included in this cross over clinical trial study. Studied population was divided into two different groups and was randomly treated for three consecutive menstrual cycles with one of the following regiments: Pyridoxine (100-200 mg/ day) or lithium (600 mg/day), each for seven days. Patients in each group were assessed for pre-menstrual symptoms with LLPDD checklist based on DSM-IV for these three months. After being drug free for a month, all patients received the second drug. Results: This research showed drug effect in premenstrual syndrome improvement (63.8 percent for lithium therapy Vs 48.1 Percent for pyridoxine therapy), especially in moods symptoms (98.7 percent for lithium therapy compared 49.4 percent for pyridoxine therapy). Conclusion: Comparing with pyridoxine, lithium is more effective in reducing the general symptoms of the luteal phase, especially mood symptoms (p value <0.05). No significant side effect of lithium was observed in this study.