TCA گلوكاگون و تاثير آن در هيپوتانسيون سرسخت ناشي از مسموميت با ضدافسردگيهاي سه حلقه اي

Glucagonʹs effect in refractory hypotension due to tricyclic antidepressant drugs toxicity

Poisoning with tricyclic antidepressant drugs (TCA) is a common situation and their hypotention and myocardial depression is refractory to conventional medical therapies. The most common cause of death is refractory hypotension. We introduce a patient referred with coma, filliform peripheral pulses, shallow breathing and not detectable blood pressure. After incubation and primary resuscitation measures, the patient was connected to ventilator and in addition to usual detoxification routines dopamine and noreadrenaline infusion was used to increase blood pressure but proved to be unsuccessful. With glucagon administration blood pressure was indeed corrected. .