مروري بر سم شناسي جونده كش هاي ضدانعقادي نسل دوم رايج در ايران

A REVIEW ON TOXICOLOGY OF THE SECOND GENERATION ANTICOAGULANT RODENTICIDES IN IRAN

The second generation anticoagulant rodenticide agents (superwarfarin agents) are threatening for health in the world and Iran.Increasing consumption of these agents is due to lack of resistance of rodents, high potency longstanding effects against first generation. This is the reason that we have to understand the management of poisoning of these agents.These agents like other warfarin agents inhibit the synthesis of vit K dependent coagulant factors and causes coagulation disorders and bleeding.Ingestion of little amount of these agents produces few symptoms of poisoning but in higher amount it may be life threatening. Management includes stabilizing the patient, increase the excretion of poisonous substances, prescribe the antipoison drugs and other supportive and symptomatic managements. We can use biological specimens like serum, plasma, urine and tissues (lung, liver and spleen) to deter- mine the type and amount of the poisonous substances in the body.The most important laboratory analytic methods of these agents are HPTLC, HPLC and GCIMS.