اثر عصاره متانولي خشخاش بر تشنج ناشي از پيكروتوكسين در موش سوري

Effects of Methanol Extract of Papaver Somniferum L. on Seizure Induced by Picrotoxin in Male Mice

Background: There are some reports on useful effects of some medicinal herbs in treatment of diseases, in traditional medicine. One of these reports is the useful effect of Papaver Somniferum L. on seizure. In this investigation, the effects of methanol extract of Papaver somniferum L. seeds on seizure induced by picrotoxin was studied in male mice. Materials and Methods: In this study the animals were pretreated with different doses of methanol extract (12.5, 25, 50, 100 and 200 mg/kg) by intraperitoneal injection. 20 minutes after the extract injection, each animal received 12mg/kg picrotoxin for induction of seizure. Latency time for beginning of seizure, duration of seizure and death time were determined in experimental and control groups. Results: The results showed that latency of the begining time of seizure was increased in groups that were pretreated with different doses of extract, specially with dose of 200mg/kg, (P<0.01). The duration of seizure increased in all experimental groups comprare to the control animals, but the severity of seizures was milder than the control group. Different doses of extract, specially dose of 50mg/kg delayed the death time in mice (P<0.05). Conclusion: The extract of Papaver Somniferum L, delayed the onset of seizure, decreased the severity of seizure induced by picrotoxin and lenghtened the death time, therefore it is a suitable agent for continuing investigation as anticonvulsant drug.