بررسي وضعيت آهن بدن در بيماران با بيماري آترواسكلروز عروق كرونر

Evaluation of Iron Status in Patients with Coronary Artery Disease

Background: Iron can cause lipid peroxidation in vivo and in vitro. Iron promotes myocardial injury in experimental animals. Low Density Lipoprotein (LDL) oxidation by oxidants including iron play a central role in atherosclerotic process, therefore, evaluation of serum iron in patients with coronary artery disease (CAD) has a significant importance. Materials and Methods: In this cross sectional prospective study, 312 patients with CAD and 63 without CAD, with known coronary anatomy by coronary angiography, were evaluated. Serum iron, ferritin, Lipoprotein (a), LDL and HDL were measured in their fasting blood sample. Patients Isere also evaluated for known CAD risk factors eg. diabetes mellitus, hypertension, cigarette smoking, family history of CAD and byperuricemia. Patients with anemia, renal and hepatic disease, history of malabsorption, hemochromatosis, chronic infection, inflammatory or immunological disorders, known neoplastic disorders and heart failure were excluded. Roth groups were identical in socio-economic status. Results: Mean serum iron level in case group (with CAD) was 12.9±4miug/L and in control group (without CAD) was 10.8±5miug/L. There was significant difference between these values (P<0.001). Mean serum ferritin level in case group was 126±7Smiug/L and 10175 miug/L in the control group. There were also significant differences between these values P<0.005. Conclusion: In regard to the results of this study which showed serum iron and ferritin level were significantly higher in groups with CAD, without interference of other known risk factors, it may be possible that iron status of body can playa role in atherosclerotic process.