كراتوكونوس و بيماريهاي مادرزادي دژنراتيو قلبي

Keratoeonus and Congenital Degenerative Heart Diseases

Background: To determine the association of congenital heart diseases with keratoconus Materials and Methods: In a case-control study, 30 consecutive patients with keratoconus and 30 age and sex matched controls were screened for congenital heart diseases approved by 2-D M.mode echocardiography. Evaluation of association between keratoconus and cardiologic abnormalities was determined by odds ratio. Results : Mitral valve prolapse(M.V.P)was found in 90%of keratoconus group and in 40% of control group (odds ratio=13.5). Also there was significant association between patent foramen ovale (63,3%. control= 26.6%, odds ratio =4.75) and tricuspid valve prolapse (40%, control= 13.3%, odds ratio=4.33) and keratoconus. Conclusion : Based on the results, it is suggested that the keratoconus is a nonspecific corneal sign of a systemic collagen metablism disease and further biochemical and clinical studies are required to resolve this question.