بررسي شيوع كلونيزاسيون روده اي انتروكوك مقاوم به وانكومايسين در بيماران بستري بيمارستان نمازي شيراز 1383

Prevalence of intestinal colonization by vancomaycin-resistant enterococci in Shiraz Namazi Hospital

Background and Aim: The aim of this cross sectional study was to determine the prevalence of intestinal colonization by vancomaycin-resistant enterococci (VRE) in Namazi Hospital in Shiraz. Materials and Methods: Serial rectal swabs were obtained every 5 days from all the 700 hospitalized patients, (from December 2003 through July 2004), and VRE (Vancomycinresistant Enterococci) were detected by disk diffusion method and then confirmed with Minimum Inhibitory Concentration dilution Method. The data collected out of interviews and patientsʹ records, were analyzed by means of chi-square test. Results: 99 (%t4) out of 700 patients were colonized by VRE. 3% of 23 patients who had negative tests for VRE, at the time of hospitalization, were colonized by resistant enterococci. In this study the prevalence of VRE showed a significant relationship with variables of age, ward, history of previous admissions, history of previous antibiotic use, duration of hospitalization, underlying disease, neutropenia, renal failure, dialysis and major surgery (p<0/05). But association between prevalence of VRE and sex, clinical outcome or conditions such as immunosuppression, cancer and diabetes were not statistically significant (p>0.05). Conclusion: This study that was the first on VRE in Iran and revealed that colonizeation with VRE has a high prevalence in Namazi Hospital and this organism might be endemic in large hospitals. Interventional strategies are required to control this emerging nosocomial infection.