كليدواژه :
تيموكينون , Thymoquinone , ايسكمي مغزي , سياهدانه , Nigella sativa , پزشكي , Lipid peroxidation , پراكسيداسيون چربي , Malondialdehyde , تيوبار بيتوريك اسيد , Thiobarbituric acid , فارماكولوژي , مالون دي آلدهايد , TBA , MDA
چكيده لاتين :
Thymoquinone is the major active constituent of the volatile oil of Nigella saliva seeds. It has been previously reported that thymoquinone prevents oxidative injury in various hepatotoxicity models and may prevent membrane lipid peroxidation. In order to clarify the effect of thymoquinone on lipid peroxidation in CNS, we induced cerebral ischemic/reperfusion injury in rats using four-vessel occlusion (4-VO) method and consequently determined malondialdehyde (MDA) levels in hippocampus based on its reaction with thiobarbituric acid (TBA). Thymoquinone (2.5-10 mg/kg), phenytoin (50 mg/kg) and control (I0 ml/kg) were administered immediately after reperfusion. The MDA level was higher in control group (normal saline) following ischemic-reperfusion than thymoquinone treated groups. The MDA levels recovered significantly upon phenytoin and thymoquinone (5, 10 mg/kg) therapy following ischemic/reperfusion. These results suggest that thymoquinone may exhibit neuroprotective effect through an inhibitory activity against lipid peroxidation during cerebral ischemia in rats.
