بررسي اثرات خواب آوري و شل كنندگي عضلاني عصاره آبي برگ گياه نوروزك در موش سفيد كوچك

Muscle relaxant and hypnotic effects of Salvia leriifolia Benth leaves extract in mice

Muscle relaxant and hypnotic effects of Salvia leriifolia Benth. aqueous decoction leaves extract was studied in mice. The aqueous decoction extract (1.15 and 1.57 g/kg, i.p.) slightly increased sleeping time up to 20.58 min versus 63.67 min in diazepam (3 mg/kg) group in thiopental-hypnosis test. The extract (0.29-2.87 mg/kg, i.p.) induced relaxation of skeletal muscle in mice verified by traction test. The extract at low dose (0.29 mg/kg) showed a muscle relaxant activity as effective as diazepam (1 mg/kg). Preliminary phytochemical test showed that the extract contains low flavonoid, rich tannin and saponin. Our observation confirmed that S. leriifolia aqueous leaves extract exerted muscle relaxant and hypnotic effects.