67- گاليوم بليومايسين GA تهيه و كنترل راديو داروي

Development of 67Ga-Bleomycin Complex for Tumor Imaging

The preparation and condition for optimization of 67Ga-labeled bleomicin complex (67Ga-BLM) were undertaken for evaluation of its in vitro/in vivo tumor imaging behavior. Bleomycin (BLM) was successively labeled with 67Ga-gallium chloride obtained from an irradiated 68Zn-metal solid target prepared by electrode position at 18 MeV. The best results were obtained at the pH=l in normal saline as the solvent at lOO^C in 30 min. Radio thin layer chromatography showed an overall radiochemical vield of 90-94% at the optimized conditions with a specific activity of about 1.39 mCi/mmole and radiochemical purity greater than 93% in 15 min. The final complex was checked by other chromatographic methods to ensure the formation of only one species followed by filtration through a 0.22u filter.