PET و كنترل كيفي آن براي تشخيص پزشكي به روش [s1 CU]-PTSMN( متيل تيوسمي كاربازون ) -N( پيروآلدييدبيس [16CU] تهيه راديوداروي

Preparation and Quality Control of [61Cu]Pyruvaldehyde-Bis (N4 -Methylthiosemicarbazone) Complex for PET Diagnosis

Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) is the most important copper radiopharmaceutical used in clinical experiments. In this work, Copper-61 (T1/2=3.33h) production process was accomplished via the nat.Zn(p,xn)61Cu, using 22MeV protons, and the current of 150 uA, resulted in 6.33 Ci of copper-61 with the production yield of 33.3 mCi/uAh. The complexing agent, PTSM, was synthesized and its structure was confirmed by the common spectroscopic methods, followed by radio labeling with 61Cu-CuCl2 The final radiopharmaceutical solution underwent common quality control tests for animal injection.