تهيه مشتق بوروناته گادواينيوم تگزاپيرين براي درمان بوسيله بدام اندازي نوترون

Synthesis of a Boronated Derivative of Gd-Texaphyrine for Potential Use in Boron Neutron Capture Therapy (BNCT)

In the last two decades treatment of brain tumors using BNCT has been performed using improved boron compounds and neutron irradiation techniques. Compounds that make use of carborane clusters, which have a high inherent boron content, should be more effective, provided, of course, the efficient and selective uptake of the boron-containing carrier molecules by cancer or other target cells. Examples of carborane cluster are the icosahedra QB10H12 carboranes. Many porphyrins and porphyrinoid compounds have demonstrated an ability to selectively accumulate in tumors, and have therefore been considered as the possible candidates for delivery of boron to malignant tissue. The texaphyrins are aromatic pent dentate macro cyclic expanded porphyrins, which have been found to be useful as MRI contrast agents, as radiation sensitizers and in photodynamic therapy (PDT). In this study, a new boronated texaphyrine for potential use in BNCT has been proposed and synthesized.