بررسي خصوصيات باليني ، سونوگرافي و آزمايشگاهي سندرم تخمدان پلي كيستيك در كرمان 1381

Polycystic ovarian syndrome: clinical, ultrasound and laboratory characteristics, kerman, 1381

Introduction: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders accounting for the majority of cases of unovulatory infertilities. It also predisposes the individuals to specific conditions including diabetes mellitus, cardiovascular disease, and breast and endometrial cancer. Regarding the geographic and racial variations of the clinical and para clinical features of this disorder, the present study was carried out to find the prevalence of these characteristics and their interrelationship in Kerman. Material and Methods: One hundred and thirty patients with clinical diagnosis of polycystic ovarian syndrome underwent pelvic ultrasound and endocrine evaluation. Cases of late onset adrenal hyperplasia, hypothyroidism and pituitary prolactinoma were excluded. Results: Ollgomenorrhea and hirsutism were the most frequent complaints (T8 and 69.2 percent, respectively). Acne was present In 25.2% of patients and 39.2% of the individuals had a normal body mass index. 81.5% (106) of cases revealed the characteristic ultrasonic picture of PCOS and in the remaining cases It was normal. There was a significant relationship between LH/FSH>2 and hirsutism. Hyperprolactinemia was significantly related to galactorrhea. There was a significant positive correlation between dehydroeplandrostrone sulfate level and LH/FSH>2. Elevated levels of 17-hydroxy progesterone were significantly more frequent in obese cases. No significant relationships were found between hormonal status and ultrasound or clinical features. Conclusions.: It can be concluded that oligomenorrhea and hirsutism are the most prevalent clinical symptoms of PCOS in Kerman. Obesity is not a prominent feature of the disease and many cases have a normal body mass Index. Some of the clinical and laboratory parameters of hyperandrogenism become more prevalent as the LH level rise. The prevalence of clinical and Para clinical characteristic of PCOS in Kerman is different from other parts of the world and this may reflect the effect of geographic and ethnic factors.