بررسي ارتباط سطح سرمي تري يدو تيروفين با عوامل خطر بيماري هاي قلبي - عروقي در مطالعه قند و ليپيدتهران

Relationship between level of T3 and cardiovascular risk factors in Tehran Lipid and Glucose Study

Introduction: Despite recent literature indicating the association between low T3 levels and cardiovascular mortality in cardiac patients, the relationship between levels of T3 and cardiovascular risk factors in normal populations has not yet been investigated. Considering the increased mortality due to coronary artery disease in our country and the necessity to identify new risk factors, this study was performed to determine the relationship between T3 concentration and cardiovascular risk factors, in individuals, aged over 50, selected from among participants of the Tehran Glucose & Lipid Study (TLGS) population. Materials and methods: The first phase of "Tehran Thyroid study" was performed within the framework of the TLGS with the aim of determining the prevalence of thyroid disorders in a subgroup of subjects of the TLGS. The population of the present study consists of subjects, aged over 50, selected from among the participants of the "Tehran Thyroid study". In 250 adults, aged > 50 yrs, the level of T3 was measured and the relationship between cardiovascular risk factors and T3 concentration was investigated. This relationship was also investigated in two subgroups of these subjects, patients with "diabetes mellitus and IGT" & subjects with ECG evidence of myocardial infarction. Since all subjects had normal T3, quartiles for T3 in normal range were calculated; first quartile: T3<132, second quartile: 132