در كاركنان مراكز بهداشتي درماني كرمانشاه در سال 1831 B ميزان پاسخ ايمني عليه واكسن هپاتيت

Immune response to hepatitis B vaccine in health care workers of Kermanshah

Background & Objectives: hepatitis B is a major health problem in Iran. Although seroconversion in vaccinated persons is estimated to be more than 90%, immune response to hepatitis B vaccine have been reported to be varied in different studies. This study was done to assess the vaccine effects in health care workers (HCWs). Materials and Methods: I this descriptive, cross sectional study, HBSAb titer in 138 HBCAb negative, vaccinated HCWs in 10 health care centers was assessed using ELISA method. Of 138 HCWs, 60.1% were females and 39.9 males. Results: 69.9% developed protective immune response. Age was a significant factor in responsiveness. Sex, weight, and last vaccination time had no significant role. Discussion: In our study, rate of immune response to hepatitis B was low. Thus, revaccination may be necessary for nonresponders. We suggest that cost-effectiveness of the Heberbiovac HB vaccine should be re-evaluated in high risk groups.