بررسي اثرات اتانول بر تغييرات بافتي جفت موش هاي باردار

Evaluation of the Effects of Ethanol on the placental Tissues of pregnant Mouse.

Evaluation of the effect of ethanol on mouseʹs placental tissues and the abortion as the result of ethanol consumption were our objectives. Female and male Balb/c strain mice were selected for this study. Pregnancy occurred and 1 mg ethanol Per each gr maternal body weight was injected intraperitoneally to the pregnant mice every day . Every problem in the process of pregnancy in both experimental and control group was recorded. Placenta which were obtained after abortion or parturition from case and control groups were examined with microscopy. Abortion in experimental group was sharply higher than control group. Changes in the placental tissue were from 7th gestational day by light microscopy. These changes were progressively greater on later days. So on the final days of pregnancy or abortion, changes were very severe. Exaggerated prolifration of connective tissues around the blood vessels and complete disintegration of placental vinous, were placental changes. By interpretation of these results, we concluded that ethanol may cause disintegration in the placental tissues and abnormal vascularization of vinous. So possibly the circulation of placenta decreases and in some cases abortion will occur.